In this article, we’ll discuss how a living organism in your backyard compost pile, Mycobacterium vaccae (M. vaccae), can act like an antidepressant once it gets inside your body. This organism acts much like an antidepressant pill, stabilizing the gut microbiome and inducing a shift toward a more proactive behavioral coping response to SD.
Immunization with Mycobacterium vaccae promotes stress resilience
Recent findings have linked the soil bacterium Mycobacterium vaccae with stress resilience in mice. Its immune-regulatory and anti-inflammatory properties were found to promote stress resilience in a “two hit” stressor model. Immunization with the bacteria changed microbiome-gut-brain axis signaling to promote stress resilience. Additionally, mice exposed to the bacterium responded differently to the stressor than those exposed to a single-hit stressor.
The impact of sleep disruption on the immune system was not fully understood. The aim of this study was to examine the protective effects of immunization with mycobacterium vaccae probiotic on stress-induced changes in sleep and to determine whether repeated immunization with M. vaccae confers stress resilience in mice. The mice were exposed to acute and repeated sleep disruptions. The immunization induced anti-inflammatory effects on immune system cells.
A recent study has shown that immunization with M. vaccae increases the proportion of Treg cells in the mesenteric lymph nodes. This result is consistent with the protective effect of the bacteria on allergic airway inflammation in the murine model of asthma. It also inhibits the inflammatory response induced by SD. Further, the immune system response to the vaccination was measurable, with the mice exhibiting reduced flight and avoidance behaviors in a stressful environment.
It stabilizes the gut microbiome
Researchers at the University of Bristol have found that M. vaccae may have antidepressant properties. The bacteria have been shown to inhibit the release of stress hormones and improve immune function. The research showed that inoculation with M. vaccae lowered anxiety levels in mice. The researchers are now working on human trials. Until now, there has not been any proof that the bacteria have a direct effect on anxiety or depression. However, these studies are promising and could eventually be used to develop new antidepressants.
The researchers also found that the mice immunized with M. vaccae had a more stable gut microbiome. The mice that were immunized with the bacteria were less likely to suffer from stress-induced colitis, a disease that is marked by cellular damage in the colon. These mice also had reduced levels of system-wide inflammation. In addition, the mice injected with Mycobacterium vaccae had higher levels of tph2, a gene that is involved in the biosynthesis of serotonin, a brain chemical that regulates mood.
It induces a shift toward a more proactive behavioral coping response to SD
A new study suggests that vaccination with Mycobacterium vaccae reduces the inflammation in the brain, thereby promoting a more proactive coping response to SD. This shift in behavior is similar to that observed in humans who receive antidepressants. The findings may have important implications for a number of health conditions, including post-traumatic stress disorder.
Mycobacterium vaccae (NCTC 11659) is a soil-derived bacterium with immunoregulatory and anti-inflammatory properties. It is thought to induce a more proactive behavioral coping response to SD through repeated immunization. Biotelemetric recordings were made on day 28 following a single or repeated administration of Mycobacterium vaccae to male C57BL/6NCrl mice. Mice were then given either a heat-killed preparation of M. vaccae or a borate-buffered saline vehicle.
It acts like an antidepressant
The bacteria Mycobacterium vaccae is a promising new tool in the fight against depression. It has been shown to affect the activity of certain neurotransmitters and inhibit cytokine production, as well as stimulate certain neurons. In this way, it may improve stress resilience and reduce anxiety. Furthermore, this organism enhances the activity of the microbiome and improves the neural activity in the brain.
Researchers have discovered that a soil bacterium, Mycobacterium vaccae, has anti-depressant properties in mice. This bacterium increases the production of serotonin, a neurotransmitter that makes people feel happier. Studies have linked a lack of serotonin in the brain to depression and anxiety, and the bacterium acts like an antidepressant without any adverse effects.